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The prognosis of patients with progressive multifocal leukoencephalopathy is poor,with few patients showing remission or surviving.We describe a 37 year old man who developed progressive multifocal leukoencephalopathy in association with sarcoidosis.Despite treatment with cytarabine and acyclovir,he continued to deteriorate.Shortly following the addition of interferon alfa,he made a dramatic improvement,regaining full functional independence.The use of interferon alfa in addition to cytarabine in such patients offers a new therapeutic approach worthy of further trial. |
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